A Complex Reaction Network Model for Spontaneous Mirror Symmetry Breaking in Viedma Deracemizations

Author:

Noble‐Terán María E.1ORCID,Cruz José‐Manuel2ORCID,Cruz‐Rosas Hugo I.1ORCID,Buhse Thomas1ORCID,Micheau Jean‐Claude3ORCID

Affiliation:

1. Centro de Investigaciones Químicas – IICBA Universidad Autónoma del Estado de Morelos Avenida Universidad 1001 62209 Cuernavaca Morelos Mexico

2. Facultad de Ciencias en Física y Matemáticas Universidad Autónoma de Chiapas 29050 Tuxtla Gutiérrez Chiapas Mexico

3. Laboratoire des IMRCP UMR au CNRS No. 5623 Université Paul Sabatier 31062 Toulouse Cedex France

Abstract

AbstractAttrition‐enhanced chiral symmetry breaking in crystals, known as Viedma deracemization, is a promising method for converting racemic solid phases into enantiomerically pure ones under non‐equilibrium conditions. However, many aspects of this process remain unclear. In this study, we present a new investigation into Viedma deracemization using a comprehensive kinetic rate equation continuous model based on classical primary nucleation theory, crystal growth, and Ostwald ripening. Our approach employs a fully microreversible kinetic scheme with a size‐dependent solubility following the Gibbs–Thomson rule. To validate our model, we use data from a real NaClO3 deracemization experiment. After parametrization, the model shows spontaneous mirror symmetry breaking (SMSB) under grinding. Additionally, we identify a bifurcation scenario with a lower and upper limit of the grinding intensity that leads to deracemization, including a minimum deracemization time within this window. Furthermore, this model uncovers that SMSB is caused by multiple instances of concealed high‐order autocatalysis. Our findings provide new insights into attrition‐enhanced deracemization and its potential applications in chiral molecule synthesis and understanding biological homochirality.

Publisher

Wiley

Subject

Physical and Theoretical Chemistry,Atomic and Molecular Physics, and Optics

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3