Affiliation:
1. Graduate School of Pharmaceutical Sciences Tohoku University 6-3 Aoba, Aramaki, Aoba-ku Sendai 980-8578 Japan
Abstract
AbstractConcise synthesis and structure‐activity relationships study of 4‐substituted 2‐azaadamantane N‐oxyls reveals that 4‐chloro‐2‐azaadamantane N‐oxyl (4‐Cl‐AZADO) is an efficient organocatalyst toward the aerobic oxidation of alcohols in the presence of NOx as a co‐catalyst. The organocatalyst was easily synthesized from 2‐adamantanone in five steps, and it showed high activity compared with many previously reported nitroxyl radical catalysts.
Funder
Ministry of Education, Culture, Sports, Science and Technology
Japan Agency for Medical Research and Development