The Asymmetric Construction α‐CF2H Pyrrolidine via 1,3‐Dipolar Cycloaddition of N‐2,2‐Difluoroethylthioisatin Ketoimines with Meldrum's Acid Derived Electron‐Deficient Olefins-Reference-Cited by-同舟云学术

The Asymmetric Construction α‐CF₂H Pyrrolidine via 1,3‐Dipolar Cycloaddition of N‐2,2‐Difluoroethylthioisatin Ketoimines with Meldrum's Acid Derived Electron‐Deficient Olefins

Published:2023-05-19 Issue:6 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Sun Shuo¹,Deng Yabo¹,Chen Danna²,Guo Hai³,Sun Mengmeng¹,He Honghua²,Yan Wenjin¹^ORCID,Huang Jinqi²

Affiliation:

1. The Institute of Pharmacology School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China

2. Affiliated Hospital of Guangdong Medical University (GDMU) Zhanjiang Guangdong 524000 China

3. The Second Clinical Medical College Lanzhou University Lanzhou Gansu 730000 China

Abstract

AbstractWe report here a directly catalytic asymmetric method in the construction of CF2H‐containing pyrrolidines. A variety of enantioenriched difluoromethylated pyrrolidine (34 examples, up to 97% ee) were obtained on a 1, 3‐dipole cycloaddition model. The subsequent hydrolysis reaction provides a new difluoromethyl substituted fused ring compound which has certain anticancer activity.

Funder

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300184

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