Catalyst‐Free Diastereoselective Halo‐Cycloacetalization of Olefinic Aldehydes-Reference-Cited by-同舟云学术

Catalyst‐Free Diastereoselective Halo‐Cycloacetalization of Olefinic Aldehydes

Published:2023-12-08 Issue:1 Volume:13 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Qiang Shengsheng¹,Chan Tsz‐Chun¹,Yeung Ying‐Yeung¹^ORCID

Affiliation:

1. Department of Chemistry and State Key Laboratory of Synthetic Chemistry The Chinese University of Hong Kong Shatin, NT, Hong Kong China

Abstract

AbstractIsochromans are valuable building blocks for the synthesis of natural products and bioactive compounds. Herein, we report a diastereoselective halo‐cycloacetalization of olefinic aldehydes and alcohols using N‐haloamides as the halogenating agents. The reaction conditions are mild and can be operated in the absence of external catalysts. Olefinic aldehydes bearing different substituents and various alcohols are compatible with the reaction protocol, giving isochroman derivatives efficiently.

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300564

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