FeCl<sub>3</sub> Catalyzed Three‐Component Synthesis of Spirochromans and Dihydrocoumarins-Reference-Cited by-同舟云学术

FeCl₃ Catalyzed Three‐Component Synthesis of Spirochromans and Dihydrocoumarins

Published:2023-08 Issue:8 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Pratap Singh Surya¹,Arora Shivani¹,Singh Anand¹²^ORCID

Affiliation:

1. Department of Chemistry Indian Institute of Technology Kanpur 208016 Kanpur Uttar Pradesh India

2. Department of Sustainable Energy Engineering Indian Institute of Technology Kanpur 208016 Kanpur Uttar Pradesh India

Abstract

AbstractAn efficient approach towards the synthesis of substituted spirochromans and dihydrocoumarins from a three‐component reaction involving aromatic aldehydes, phenols and phenylene dithiolanes is described. This FeCl3 catalyzed reaction utilizes either aromatic aldehydes or their acetals for condensation with phenols to generate o‐quinone methides in situ which further undergo a formal [4+2] cyclization with phenylene dithiolanes. Careful control of temperature allows direct access to dihydrocoumarins by the removal of the thioacetal moiety.

Funder

Science and Engineering Research Board

Indian Institute of Technology Kanpur

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300279

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