Affiliation:
1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China 96 Jinzhai Road 230026 Hefei Anhui China
2. Institution School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica Shandong First Medical University & Shandong Academy of Medical Sciences NHC Key Laboratory of biotechnology drugs Shandong Academy of Medical Sciences) Key Lab for Rare & Uncommon Diseases of Shandong Province 250117 Jinan Shandong China
Abstract
AbstractThe first example of merging photoredox catalysis and copper catalysis for 1,4‐difunctionalization of 1,3‐enynes via 1,5‐HAT (hydrogen atom transfer) has been developed. The synthetic strategy exploits a radical translocation from an oxygen‐centered to a carbon‐centered radical with a subsequent radical addition to the 1,3‐enynes, affording tetrasubstituted allenenitriles in up to 90% yield. This strategy has mild reaction conditions, broad substrate scope and excellent functional group tolerance.
Funder
National Natural Science Foundation of China
Cited by
1 articles.
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