Visible Light‐Promoted Three‐Component Reaction for the Synthesis of Fluoroalkyl‐Substituted Amides from Isocyanides

Abstract

AbstractA visible‐light‐promoted radical fluoroalkylation has been achieved through a three‐component reaction of fluoroalkyl reagents, isocyanides and water, affording fluoroalkyl‐substituted amides in good yields. This reaction involves the generation of the nitrilium cation by single‐electron reduction of the imidoyl radical and a subsequent nucleophilic attack by water. Mechanistic studies support the generation of the imidoyl radical through the capture of the fluoroalkyl‐substituted imidoyl radical species.