Synthesis of Thienyl Polycyclic Fused Indoles Based on the Indium Catalyzed Prins/Friedel‐Crafts Tandem Reaction-Reference-Cited by-同舟云学术

Synthesis of Thienyl Polycyclic Fused Indoles Based on the Indium Catalyzed Prins/Friedel‐Crafts Tandem Reaction

Published:2023-05-11 Issue:6 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Huang Zhi‐Bang¹,Zhao Ming‐Hao¹,Liu Xu¹,Wang Lijia¹²^ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development Department of Chemistry East China Normal University 3663 North Zhongshan Road Shanghai 200062 China

2. Shanghai Frontiers Science Center of Molecule Intelligent Syntheses East China Normal University 3663 North Zhongshan Road Shanghai 200062 China

Abstract

AbstractAn indium catalyzed Prins/Friedel‐Crafts tandem cyclization reaction has been developed. This reaction provides an efficient and practical method to construct a variety of polycyclic indole frameworks with high diastereoselectivity and good functional group tolerance (30 examples, up to 98% yield with >95 : 5 dr). The resulting products are easily accessible for further chemical transformations.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300147

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