Rhodium‐Catalyzed Regioselective C7<sub>Ar</sub>‐Functionalization of Tryptophan with Quinones and its Late Stage Peptide Exemplification-Reference-Cited by-同舟云学术

Rhodium‐Catalyzed Regioselective C7_Ar‐Functionalization of Tryptophan with Quinones and its Late Stage Peptide Exemplification

Published:2023-11-30 Issue:12 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Tank Disha Harsukhbhai¹,Kharat Narendra Dinkar¹,Bajaj Kiran²,Panda Siva S.³,Sakhuja Rajeev¹^ORCID

Affiliation:

1. Department of Chemistry Birla Institute of Technology and Science Pilani Rajasthan 333031 India

2. Department of Chemistry Amity Institute of Applied Sciences Amity University Noida Uttar Pradesh India

3. Department of Chemistry and Biochemistry & Department of Biochemistry and Molecular Biology Augusta University Augusta GA 30912 USA) Please delete this box prior to submission.

Abstract

AbstractPivaloyl‐directed Rh(III)‐catalyzed regioselective C7Ar‐H functionalization of protected tryptophans were accomplished with 1,4‐benzoquinones, furnishing a series of quinone‐appended tryptophan‐based unnatural amino acids in high yields. Further, the late stage functionalization on tryptophan‐containing dipeptides was achieved with 1,4‐benzoquinones in moderate reactivity.

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300503

Reference77 articles.

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3. Approaches for enhancing oral bioavailability of peptides and proteins

4. Peptidomimetic toolbox for drug discovery

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