Benzotriazolium Ylides‐Assisted Multicomponent Diastereoselective Synthesis of Activated Tetra‐ and Penta‐Substituted Cyclopropanes

Author:

Xia Yaolin1,Zhang Qian1,Lin Xinkui1,Lin Shuizhen1,Ma Xiaoyu1,Xiao Xiaohui1,Huang Xiaolei1ORCID

Affiliation:

1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials Science Zhejiang Normal University Jinhua Zhejiang 321004 P. R. of China

Abstract

AbstractA one‐pot three component reaction of benzotriazolium ylides, aldehydes or ketones, and 1,3‐dicarbonyl compounds has been developed for the synthesis of activated tetra‐ and penta‐substituted cyclopropanes. The transformation features high reactivity and diastereoselectivity, broad substrate scope, room temperature, and simple operation.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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