Rapid Construction of Hexahydro‐1<i>H</i>‐pyrrolo[3,2‐<i>c</i>]pyridines with Functionalized 1,3‐Enynes and Imines via Palladium Catalysis-Reference-Cited by-同舟云学术

Rapid Construction of Hexahydro‐1H‐pyrrolo[3,2‐c]pyridines with Functionalized 1,3‐Enynes and Imines via Palladium Catalysis

Published:2023-05-25 Issue:6 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Huang Jin‐Yu¹,Hu Yuan¹,Chen Zhi‐Chao¹,Zhan Gu²,Du Wei¹,Chen Ying‐Chun¹

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University Chengdu 610041 China

2. State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

Abstract

AbstractPresented herein is a palladium catalyzed tandem reaction between 3‐aminoethyl group tethered 1,3‐enynes and imines, proceeding through a cascade vinylogous addition/reductive elimination/protonation/allylic amination and 1,3‐hydrogen transfer sequence. A collection of complex hexahydro‐1H‐pyrrolo[3,2‐c]pyridine architectures were straightforwardly constructed in moderate yields and diastereoselectivity.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300225

Reference36 articles.

1. Martinelline and Martinellic Acid, Novel G-Protein Linked Receptor Antagonists from the Tropical Plant Martinella iquitosensis (Bignoniaceae)

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3. Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane

4. Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold

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