Affiliation:
1. Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University 100875 Beijing P. R. China
Abstract
AbstractThe reactivity of N‐Heterocyclic carbene (NHC)‐bound alkynyl acyl azoliums is underexplored in chemistry. We herein reported an NHC‐catalyzed [3+3] annulation of alkynyl acyl azoliums with β‐keto esters. The strategy features mild reaction conditions and exhibits broad substrates scope, delivering a wide range of tri‐substituted α‐pyrones in moderate to excellent yields (up to 95%). This approach extends the reactivity of alkynyl acyl azoliums to β‐keto esters binucleophiles.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Beijing Municipality