Affiliation:
1. Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province School of Pharmacy Zunyi Medical University Zunyi Guizhou 563000 People's Republic of China
2. Department of Nuclear Medicine Affiliated Hospital of Zunyi Medical University Zunyi Medical University Zunyi Guizhou 563000 People's Republic of China
Abstract
AbstractSecondary trifluoromethylated alkyl bromides are versatile building blocks in the synthesis of fluorine‐containing aliphatic compounds. However, current methods of preparation are limited. In this study, we have developed a general deaminative cross‐coupling of Katritzky salts with 2‐bromo‐3,3,3‐trifluoropropene (BTP) as a route to α‐trifluoromethylated alkyl bromides that is driven by an electron‐donor‐acceptor (EDA) complex. The resultant products can be readily converted to α‐trifluoromethyl borates and α‐trifluoromethyl alcohols, enriching the current toolbox for synthesizing trifluoromethylated aliphatic compounds with wide‐ranging applications.
Funder
National Natural Science Foundation of China