Synthesis of Secondary Trifluoromethylated Alkyl Bromides with Further Conversion to Boronic Esters and Alcohols

Abstract

AbstractSecondary trifluoromethylated alkyl bromides are versatile building blocks in the synthesis of fluorine‐containing aliphatic compounds. However, current methods of preparation are limited. In this study, we have developed a general deaminative cross‐coupling of Katritzky salts with 2‐bromo‐3,3,3‐trifluoropropene (BTP) as a route to α‐trifluoromethylated alkyl bromides that is driven by an electron‐donor‐acceptor (EDA) complex. The resultant products can be readily converted to α‐trifluoromethyl borates and α‐trifluoromethyl alcohols, enriching the current toolbox for synthesizing trifluoromethylated aliphatic compounds with wide‐ranging applications.