An Efficient Synthesis of α‐Sulfonamide Phosphonates through Metal‐Free Three‐Component Reaction

Author:

Ramani Arti1,Bhavyesh Desai1,Kanta Koppolu Mani2,Chinna Ashalu Kashamalla3,Begari Eeshwaraiah4,Naveen Togati1ORCID

Affiliation:

1. Department of Chemistry Sardar Vallabhbhai National Institute of Technology 395 007 Surat Gujarat India

2. Department of Biology Indian Institute of Science Education and Research 517 507 Tirupati Andhra Pradesh India

3. Department of Chemistry School of Science, Indrashil University Rajpur 382 715 Kadi Gujarat India

4. School of Applied Material Sciences Central University of Gujarat 382 030 Gandhinagar India

Abstract

AbstractA metal‐free three‐component reaction for the direct synthesis of α‐sulfonamide phosphonates involving sulfonamide derivatives, benzaldehyde derivatives, and diethyl phosphite, has been achieved with high yields using ethanol as a green solvent. This efficient method reduces reaction time and minimizes the use of excess reagents. Hitherto, no reports have been found in the literature for the direct synthesis of α‐sulfonamide phosphonates from the readily available aldehydes, diethyl phosphite, and sulfonamides, emphasizing the novelty and significance of this work.

Publisher

Wiley

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