Affiliation:
1. Department of Chemical and Environmental Engineering Shanghai Institute of Technology 100 Hai Quan Rd. 201418 Shanghai P. R. China
2. Shanghai Key Laboratory of Chemical Assessment and Sustainability Tongji University 1239 Si Ping Rd. 200092 Shanghai P. R. China
Abstract
AbstractThis work demonstrates a TfOH‐catalyzed multicomponent reaction. Using propargylic alcohols, aldehydes and sulfonamides as the substrates, a wide variety of acyclic α‐arylidene β‐aminoketones were prepared in high yields. The reaction mechanism likely involved a sulfonyl imide intercepted Meyer‐Schuster rearrangement combined with 1,3‐aryl migration. The present transformations proceeded with a low catalyst loading and permitted a large number of substituents on all reactants. The superior atom economy, high yield and convenient operation of this reaction suggest that it may be a practical alternative for the construction of acyclic α‐arylidene β‐aminoketones.
Funder
Science and Technology Commission of Shanghai Municipality
Shanghai Municipal Education Commission
Cited by
5 articles.
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