Affiliation:
1. College of Chemistry & Materials Science Fujian Normal University Fuzhou 350007 P. R. China
2. State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences 155 Yangqiao Road West Fuzhou 350002 P. R. China
3. Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108 P. R. China
Abstract
AbstractHydrogenated pyrans are prevalent structural units existed in many biologically active compounds, capturing the attention of pharmacologists due to their potential therapeutic applications. Among various synthetic routes, the hetero‐Diels‐Alder (HDA) reaction stands out as a common and effective approach. The objective of this study was to employ HDA reaction in conjunction with the dehydrogenative oxidation strategy for saturated ketones to synthesize hydrogenated pyran compounds. Through systematic screening and optimization of reaction conditions, a convenient approach for the synthesis of multi‐substituted 2,3‐dihydro‐4H‐pyran compounds has been developed. Furthermore, a detailed mechanistic investigation has been performed to get a deep understanding of the reaction.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China