Macrocyclization Strategies Towards the Synthesis of Amphidinolide Natural Products

Author:

Chatterjee Bhaskar1,Mondal Dhananjoy2,Bera Smritilekha2ORCID

Affiliation:

1. Department of Chemistry Nabadwip Vidyasagar College 741302 Nabadwip West Bengal India

2. School of Chemical Sciences Central University of Gujarat 382030 Gandhinagar Gujarat (India

Abstract

Abstractdinoflagellates amphidinolide group of natural products have drawn the attention of the synthetic community owing to their natural scarcity, variation in ring size (12‐ to 27‐membered), and architectural complexity. The manifold strategies for creating the unique macrocyclic framework of amphidinolides, overcoming the entropy barrier of cyclisation, in good yields and selectivity, are highly encouraging as this platform provides an opportunity to develop compounds for structure‐activity relationship studies. This review emphasizes various methods of intramolecular C−C and C−O bond‐forming reactions for constructing the macrocyclic structure of different naturally occurring molecules of amphidinolide family.

Publisher

Wiley

Subject

Organic Chemistry

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