Affiliation:
1. Department of Organic Chemistry St. Petersburg State University of Chemistry and Pharmacy St. Petersburg 197376 Russia
2. Department of Analytical Chemistry St. Petersburg State University of Chemistry and Pharmacy St. Petersburg 197376 Russia
3. Department of Crystallography Faculty of Geology St. Petersburg State University University Emb. 7/9 199034 St. Petersburg Russia
Abstract
AbstractA simple methodology has been developed for the synthesis of previously unstudied N‐substituted glutarimide derivatives – (Z)‐1‐(aryl(arylimino)methyl)piperidine‐2,6‐diones 4 a–p obtained in one step from C,N‐diarylformamidines 1 a–p and glutaric anhydride 6 with product yields from 46 up to 88 % and chromatographic purity from 94 to 99 %. The structures of the obtained compounds were proved using NMR spectroscopy 1H, 13C, X‐ray diffraction analysis, mass spectroscopy, and elemental analysis. An in vivo study of the analgesic activity of a representative of series 4 a was carried out.