Synthesis of Carbazolylamines through Brønsted Acid‐Catalyzed Direct Electrophilic Aminations-Reference-Cited by-同舟云学术

Synthesis of Carbazolylamines through Brønsted Acid‐Catalyzed Direct Electrophilic Aminations

Published:2024-08-21 Issue: Volume: Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Liu Zizhen¹²,Zhai Zhiguang³,Wu Daoshun²,Wei Jianhe²,Yang Zhen⁴,Zhang Jie¹,Wang Lei²^ORCID

Affiliation:

1. The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan Shihezi University Shihezi 832004 P.R. China

2. Institute of Medicinal Plant Development Chinese Academy of Medical Science &Peking Union Medical College Beijing 100193 P.R. China

3. Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences Beijing 100700 P.R. China

4. Jilin Academy of Traditional Chinese Medical Science Changchun 130021 P.R. China

Abstract

AbstractA Brønsted acid catalyzed direct and dual C−H amination of carbazoles and indolocarbazoles with N‐Ts iminoquinone acetal is reported. It is characterized that the mentioned C−H amination was determined by the selection of catalysts and the molar ratio of the starting materials. The efficiency of this protocol was showcased by diverse carbazolylamine and indolocarbazolylamine assemblies. The late‐stage functionalization of a series of natural products fully illustrates the synthetic value of this methodology.

Publisher

Wiley

Reference51 articles.

1. A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

2. An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds

4. Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids

5. Chemistry and Properties of Indolocarbazoles