Affiliation:
1. Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University) College of Chemistry Fuzhou University Fuzhou 350108 China
Abstract
AbstractWe herein report a cobalt‐catalyzed intramolecular oxytrifluoromethylation of N‐allylamides for the efficient synthesis of trifluoromethyl‐containing oxazolines with Togni's reagent II as the trifluoromethyl precursor. The protocol features mild reaction conditions and good functional group compatibility. Preliminary mechanistic investigations suggest the involvement of free radicals in this transformation.
Funder
National Natural Science Foundation of China
Fuzhou University