Photoredox‐Catalyzed Three‐Component Difluoroalkylation of Quinoxalin‐2(1H)‐ones with Unactivated Vinylarenes and [Ph3PCF2H]+Br−-Reference-Cited by-同舟云学术

Photoredox‐Catalyzed Three‐Component Difluoroalkylation of Quinoxalin‐2(1H)‐ones with Unactivated Vinylarenes and [Ph₃PCF₂H]⁺Br⁻

Published:2023-09-20 Issue:11 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Xu Yuandong¹,Qu Hongzhao¹,Yuan Jinwei¹^ORCID,Guo Na²,Yang Liangru¹,Yin Yanli²,Qu Lingbo³,Mao Jian⁴

Affiliation:

1. School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou 450001 P. R. China

2. College of Advanced Interdisciplinary Science and Technology Henan University of Technology Zhengzhou 450001 P. R. China

3. College of Chemistry Zhengzhou University Zhengzhou 450001 P. R. China

4. Tobacco Research Institute of China National Tobacco Company Zhengzhou 450001 P. R. China

Abstract

AbstractAn efficient synthesis of a variety of 3‐difluoroalkyl quinoxalin‐2(1H)‐ones via a photoredox‐catalyzed three‐component reaction between quinoxalin‐2(1H)‐ones, vinylarenes, with inexpensive and easily accessible difluoromethyltriphenyl phosphonium bromide salt as the difluoromethylated reagent is described. This protocol shows excellent reactivity, providing a wide range of difluoroalkyl‐substituted quinoxalin‐2(1H)‐ones in moderate to excellent yields under mild conditions. A difluoroalkyl radical intermediate was involved in this three‐component transformation.

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300405

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