Rapid Identification of Enamine‐based Organocatalysts for Quaternary Carbon‐containing Aldol Reactions via Fluorescence‐based Screening-Reference-Cited by-同舟云学术

Rapid Identification of Enamine‐based Organocatalysts for Quaternary Carbon‐containing Aldol Reactions via Fluorescence‐based Screening

Published:2023-06-26 Issue:7 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Ito Hiroshi¹,Yoshida Yuya²,Masuda Tsuguya¹,Sasaki Aiko¹,Imoto Kyosuke³,Sato Kohei¹²³⁴,Narumi Tetsuo¹²³⁴,Mase Nobuyuki¹²³⁴^ORCID

Affiliation:

1. Department of Engineering Graduate School of Integrated Science and Technology Shizuoka University 3-5-1 Johoku Hamamatsu Shizuoka 432-8561 Japan

2. Graduate School of Science and Technology Shizuoka University 3-5-1 Johoku Hamamatsu Shizuoka 432-8561 Japan

3. Department of Applied Chemistry and Biochemical Engineering Faculty of Engineering Shizuoka University 3-5-1 Johoku Hamamatsu Shizuoka 432-8561 Japan

4. Research Institute of Green Science and Technology Shizuoka University 3-5-1 Johoku Hamamatsu Shizuoka 432-8561 Japan

Abstract

AbstractFluorescent sensors can directly monitor the progression of chemical transformations through increases in fluorescence intensity to allow rapid identification of superior organocatalytic systems. Based on data from more than 4,000 screenings, a combination of pyrrolidine and isophthalic acid was identified as a catalyst template for the quaternary carbon‐containing aldol reaction. Following fine‐tuning of the catalyst template, 5‐hydroxy isophthalic acid was confirmed as an additive with high reactivity.

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300236

Reference29 articles.

1. High Throughput Strategies for the Discovery and Optimization of Catalytic Reactions

2. Hochdurchsatzstrategien zur Entdeckung und Optimierung katalytischer Reaktionen

3. High-Throughput Synthesis and Screening of Titania-Based Photocatalysts

4. Catalyst–Substrate Coimmobilization: A Strategy for Catalysts Discovery in Split-and-Mix Libraries