Affiliation:
1. Institute of Mass Spectrometry School of Materials Science and Chemical Engineering Ningbo University Ningbo 315211 P. R. China
2. School of Chemistry and Chemical Engineering Zhejiang Sci-Tech University Hangzhou 310018 China
Abstract
AbstractA palladium‐catalyzed cascade cyclization and alkynylation of 2‐alkynylphenols with bromoalkynes to the synthesis of 3‐alkynylbenzofuran scaffolds has been developed. A variety of 3‐alkynylbenzofuran derivatives were prepared in good yields under mild conditions. Notably, this protocol was applied to the late‐stage modification of bioactive molecule.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
National Key Research and Development Program of China
Key Research and Development Program of Zhejiang Province
Natural Science Foundation of Zhejiang Province