Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development

Author:

Lancman Joseph J.1ORCID,Hasso Sean M.2,Suzuki Takayuki3ORCID,Kherdjemil Yacine45,Kmita Marie456,Ferris Andrea7,Dong P. Duc S.18,Ros Marian A.910,Fallon John F.11

Affiliation:

1. Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute La Jolla California USA

2. Heat Biologics Morrisville North Carolina USA

3. Department of Animal Sciences Graduate School of Bioagricultural Sciences, Nagoya University Nagoya Japan

4. Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal Montréal Québec Canada

5. Département de Médecine Université de Montréal Montréal Québec Canada

6. Department of Experimental Medicine McGill University Montreal Quebec Canada

7. Center for Cancer Research, National Cancer Institute Frederick Maryland USA

8. Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute La Jolla California USA

9. Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas−Universidad de Cantabria−Sociedad para al Desarrollo Cantabria Santander Spain

10. Departamento de Anatomía y Biología Celular, Facultad de Medicina Universidad de Cantabria Santander Spain

11. Department of Anatomy University of Wisconsin Madison Madison Wisconsin USA

Funder

National Institute of Child Health and Human Development

Publisher

Wiley

Subject

Developmental Biology

Reference64 articles.

1. Sarcopterygian fin ontogeny elucidates the origin of hands with digits

2. Establishing the pattern of the vertebrate limb;McQueen C;Development,2020

3. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity;Litingtung Y;Nature,2002

4. Hedgehog‐regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb;Wang B;Cell,2000

5. Vertebrate limb development: moving from classical morphogen gradients to an integrated 4‐dimensional patterning system;Bénazet J‐D;Csh Perspect Biol,2009

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