Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice

Author:

van de Ven Marieke12,van der Burg Eline1,van der Gulden Hanneke1,Klarenbeek Sjoerd1,Bouwman Peter1,Jonkers Jos1

Affiliation:

1. Division of Molecular Pathology and Cancer Genomics Netherlands; The Netherlands Cancer Institute; Amsterdam The Netherlands

2. MCCA Preclinical Intervention Unit; The Netherlands Cancer Institute; Amsterdam The Netherlands

Funder

Seventh Framework Programme

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference49 articles.

1. How many more breast cancer predisposition genes are there?;Easton;Breast Cancer Res BCR,1999

2. Hereditary breast cancer: new genetic developments, new therapeutic avenues;Campeau;Hum Genet,2008

3. Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE;Mavaddat;J Natl Cancer Inst,2013

4. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: results from three US population-based case-control studies of ovarian cancer;Whittemore;Am J Hum Genet,1997

5. Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada;Risch;J Natl Cancer Inst,2006

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