Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice

Author:

Teng Yuan-Chi12,Neo Jenq Chyuan2,Wu Jaw-Ching34,Chen Yi-Fan5,Kao Cheng-Heng6,Tsai Ting-Fen12789

Affiliation:

1. Program in Molecular Medicine, School of Life Sciences; National Yang-Ming University and Academia Sinica; Taipei Taiwan

2. Department of Life Sciences and Institute of Genome Sciences; National Yang-Ming University; Taipei Taiwan

3. Institute of Clinical Medicine; National Yang-Ming University; Taipei Taiwan

4. Translational Research Division, Medical Research Department; Taipei Veterans General Hospital; Taipei Taiwan

5. The PhD Program for Translational Medicine, College of Medical Science and Technology; Taipei Medical University; Taipei Taiwan

6. Center of General Education; Chang Gung University; Taoyuan Taiwan

7. Genome Research Center; National Yang-Ming University; Taipei Taiwan

8. Aging and Health Research Center; National Yang-Ming University; Taipei Taiwan

9. Institute of Molecular and Genomic Medicine; National Health Research Institutes; Zhunan Taiwan

Funder

Taipei Veterans General Hospital

Center of Excellence for Cancer Research at Taipei Veterans General Hospital

Ministry of Science and Technology

Ministry of Education, Aim for the Top University Plan

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference46 articles.

1. Epidemiology of hepatocellular carcinoma in the United States: Where are we? Where do we go?;El-Serag;Hepatology,2014

2. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma;Arzumanyan;Nature Rev Cancer,2013

3. Epidemiology of viral hepatitis and hepatocellular carcinoma;El-Serag;Gastroenterology,2012

4. An overview of hepatitis B virus surface antigen mutant in the Asia Pacific;Hudu;Curr Issues Mol Biol,2014

5. Hepatitis B virus genetic variants: biological properties and clinical implications;Tong;Emerg Microbes Infect,2013

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