Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged VL and VH genes during clonal expansion of B cells in splenic germinal centers-Reference-Cited by-同舟云学术

Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged VL and VH genes during clonal expansion of B cells in splenic germinal centers

Published:2000-12 Issue:12 Volume:30 Page:3634-3644
ISSN:0014-2980
Container-title:European Journal of Immunology
language:en
Short-container-title:Eur. J. Immunol.

Author:

Sehgal Devinder,Schiaffella Enrico,Anderson Arthur O.,Mage Rose G.

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference40 articles.

1. Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: Implications for the generation of antibody diversity

2. Somatic diversification of immunoglobulin heavy chain VDJ genes: Evidence for somatic gene conversion in rabbits

3. Preferrential rearrangement in normal rabbits of the 3′ VHa allotype gene that is deleted inAlicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences

4. Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms

5. The Appendix Functions as a Mammalian Bursal Equivalent in the Developing Rabbit

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