Rationale and design of a multicentre, randomized, placebo-controlled trial of mirabegron, a Beta3-adrenergic receptor agonist on left ventricular mass and diastolic function in patients with structural heart disease Beta3-left ventricular hypertrophy (Be

Author:

Pouleur Anne-Catherine1,Anker Stefan23,Brito Dulce4,Brosteanu Oana5,Hasenclever Dirk6,Casadei Barbara7,Edelmann Frank8910,Filippatos Gerasimos11,Gruson Damien12,Ikonomidis Ignatios11,Lhommel Renaud13,Mahmod Masliza14,Neubauer Stefan14,Persu Alexandre1,Gerber Bernhard L.1,Piechnik Stefan14,Pieske Burkert891015,Pieske-Kraigher Elisabeth7,Pinto Fausto3,Ponikowski Piotr1617,Senni Michele18,Trochu Jean-Noël1920,Van Overstraeten Nancy1,Wachter Rolf2122,Balligand Jean-Luc23

Affiliation:

1. Cardiovascular Department; Cliniques Universitaires Saint-Luc, Université catholique de Louvain; Brussels Belgium

2. Innovative Clinical Trials, Department of Cardiology and Pneumology; University Medical Center Göttingen (UMG); Göttingen Germany

3. Division of Cardiology and Metabolism-Heart Failure, Cachexia and Sarcopenia, Department of Cardiology, Berlin Brandenburg Center for Regenerative Therapies; Charité University of Medicine; Berlin Germany

4. Department of Cardiology, CHLN, CCUL (Cardiovascular Centre), AIDFM; Hospital de Santa Maria, Universidade de Lisboa; Lisbon Portugal

5. Clinical Trial Centre Leipzig-ZKS, Faculty of Medicine; Leipzig University; Leipzig Germany

6. Institute for Medical Informatics, Statistics & Epidemiology-IMISE, Faculty of Medicine; Leipzig University; Leipzig Germany

7. Division of Cardiovascular Medicine, Radcliffe Department of Medicine; University of Oxford, John Radcliffe Hospital; Oxford UK

8. Department of Internal Medicine and Cardiology; Charité-Universitätsmedizin Berlin-Campus Virchow Klinikum; Berlin Germany

9. German Center for Cardiovascular Research (DZHK), Partner Site; Berlin Germany

10. Berlin Institute of Health (BIH); Berlin Germany

11. National and Kapodistrian University of Athens, School of Medicine and Department of Cardiology, Heart Failure Unit; Athens University Hospital Attikon; Athens Greece

12. Clinical Biology Department; Cliniques Universitaires Saint-Luc, Université catholique de Louvain; Brussels Belgium

13. Nuclear Medicine Department; Cliniques Universitaires Saint-Luc, Université catholique de Louvain; Brussels Belgium

14. Cardiovascular Imaging Core Laboratory, Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine; University of Oxford; Oxford UK

15. Department of Internal Medicine and Cardiology; German Heart Institute; Berlin Germany

16. Department of Heart Diseases; Wrocław Medical University; Wrocław Poland

17. Cardiology Department; Military Hospital; Wrocław Poland

18. Department Cardiovascular Medicine, Cardiology Division; Papa Giovanni XXIII Hospital; Bergamo Italy

19. Institut du thorax; Centre Hospitalier Universitaire de Nantes; Nantes France

20. Medical School, University of Nantes; Nantes France

21. Clinic for Cardiology and Pneumology; University of Göttingen Medical Centre; Göttingen Germany

22. DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen; Göttingen Germany

23. Department of Medicine, Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC); Cliniques Universitaires Saint-Luc, Université catholique de Louvain; B1.53.09, 52 avenue Mounier 1200 Brussels Belgium

Funder

Fondation Nationale de la Recherche Scientifique of the Belgian Government

British Heart Foundation Centre of Research Excellence, Oxford

European Union's Horizon 2020 research and innovation programme

National Institute for Health Research Biomedical Research Centre, Oxford

British Heart Foundation

European Union Horizon 2020 grant

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

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