Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer-Reference-Cited by-同舟云学术

Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer

Published:2019-03 Issue:8 Volume:120 Page:12311-12320
ISSN:0730-2312
Container-title:Journal of Cellular Biochemistry
language:en
Short-container-title:J Cell Biochem

Author:

Gao Linbo¹²³^ORCID,Yuan Fang¹,Che Guanglu⁴,Xiao Xiao¹,Nie Xinwen¹,Wang Yanyun¹,Jia Jin²,Kong Ah‐Ng³^ORCID,Zhang Lin¹²

Affiliation:

1. Laboratory of Molecular Translational Medicine Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University Chengdu Sichuan People's Republic of China

2. Department of Obstetrics and Gynecology West China Second University Hospital, Sichuan University Chengdu Sichuan People’s Republic of China

3. Department of Pharmaceutics Ernest Mario School of Pharmacy, Rutgers University Piscataway New Jersey

4. Department of Laboratory Medicine West China Second University Hospital, Sichuan University Chengdu Sichuan People’s Republic of China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.28495

Reference49 articles.

1. An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

2. The Cap“n”Collar basic leucine zipper transcription factor Nrf2 (NF‐E2 p45‐related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes;McMahon M;Cancer Res,2001

3. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

4. Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

5. Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

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