Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene

Author:

Luijten Mirjam1,Ball Nicholas S.2,Dearfield Kerry L.3,Gollapudi B. Bhaskar4,Johnson George E.5ORCID,Madia Federica6,Peel Lauren7,Pfuhler Stefan8,Settivari Raja S.9,Burg Wouter10,White Paul A.11,Benthem Jan1

Affiliation:

1. Centre for Health ProtectionNational Institute for Public Health and the Environment (RIVM) Bilthoven The Netherlands

2. The Dow Chemical Company Horgen Switzerland

3. Burke Virginia

4. Center for Health SciencesExponent, Inc. Alexandria Virginia

5. Swansea University Medical School, Swansea University Swansea United Kingdom

6. European Commission, Joint Research Centre (JRC) Ispra Italy

7. Health and Environmental Sciences Institute Washington District of Columbia

8. Procter & Gamble Mason Ohio

9. Corteva Agriscience Newark Delaware

10. Centre for Safety of Substances and ProductsNational Institute for Public Health and the Environment (RIVM) Bilthoven The Netherlands

11. Department of BiologyUniversity of Ottawa Ottawa Ontario Canada

Funder

Health and Environmental Sciences Institute

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics(clinical),Epidemiology

Reference133 articles.

1. AGS (Committee on Hazardous Substances).2016. Technical Rules for Hazardous Substances Risk (TRGS 910): related concept of measures for activities involving carcinogenic hazardous substanceshttps://www.baua.de/EN/Service/Legislative-texts-and-technical-rules/Rules/TRGS/pdf/TRGS-910.pdf?__blob=publicationFile&v=2. Accessed 23 October 2019.

2. Hprt mutant frequency and p53 gene status in mice chronically exposed by inhalation to benzene

3. Tests for gene mutational activity in the L5178Y/TK assay system;Amacher DE;Prog Mutat Res,1985

4. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

5. The use of biomonitoring data in exposure and human health risk assessment: benzene case study

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