Neutrophilic Dermatoses

Abstract

Abstract The neutrophilic dermatoses are a collection of non‐infectious dermatoses involving triggering of inflammation in the context of a reduced threshold for neutrophilic inflammation. Genetic factors have been identified in rare cases and numerous predisposing diseases play a role. They are best described as autoinflammatory conditions whereby the triggering of the inflammatory process begins with abnormal activation of the innate immune system, distinct from an autoimmune process involving T cells or antibody production. Two classical neutrophilic dermatoses exist. Pyoderma is distinguished by the tendency for ulceration and tissue destruction. Sweet syndrome is generally more time limited with full recovery expected. Multiple variants exist and the optimal treatment strategies have not been agreed.