Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

Author:

Yu Mengsi1,Wang Zhiying1,Wang Dongmin2,Aierxi Milikemu1,Ma Zhanjun3,Wang Yonggang14

Affiliation:

1. The Second Clinical Medical College Lanzhou University Lanzhou China

2. Medical College of Northwest Minzu University Lanzhou China

3. Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials Université Catholique de Louvain, UCLouvain Brussels Belgium

4. Department of Orthopedics Lanzhou University Second Hospital Lanzhou China

Abstract

AbstractSpinal cord injury (SCI) is a medical condition that results from severe trauma to the central nervous system; it imposes great psychological and economic burdens on affected patients and their families. The dynamic balance between reactive oxygen species (ROS) and antioxidants is essential for maintaining normal cellular physiological functions. As important intracellular signaling molecules, ROS regulate numerous physiological activities, including vascular reactivity and neuronal function. However, excessive ROS can cause damage to cellular macromolecules, including DNA, lipids, and proteins; this damage eventually leads to cell death. This review discusses the mechanisms of oxidative stress in SCI and describes some signaling pathways that regulate oxidative injury after injury, with the aim of providing guidance for the development of novel SCI treatment strategies.

Funder

Natural Science Foundation of Gansu Province

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

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