Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation-Reference-Cited by-同舟云学术

Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation

Published:2021-06-11 Issue:9 Volume:30 Page:1833-1853
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Swint‐Kruse Liskin¹^ORCID,Martin Tyler A.¹,Page Braelyn M.¹,Wu Tiffany¹,Gerhart Paige M.¹,Dougherty Larissa L.¹²,Tang Qingling¹,Parente Daniel J.³,Mosier Brian R.⁴,Bantis Leonidas E.⁴,Fenton Aron W.¹

Affiliation:

1. Department of Biochemistry and Molecular Biology The University of Kansas Medical Center Kansas City Kansas USA

2. Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth College Hanover New Hampshire USA

3. Department of Family Medicine and Community Health The University of Kansas Medical Center Kansas City Kansas USA

4. Department of Biostatistics and Data Science The University of Kansas Medical Center Kansas City Kansas USA

Funder

National Institutes of Health

W. M. Keck Foundation

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.4136

Reference87 articles.

1. Performance of computational tools in evaluating the functional impact of laboratory-induced amino acid mutations

2. Computational predictors fail to identify amino acid substitution effects at rheostat positions

3. Rheostat positions: A new classification of protein positions relevant to pharmacogenomics

4. RheoScale: A tool to aggregate and quantify experimentally determined substitution outcomes for multiple variants at individual protein positions

5. Rheostats and Toggle Switches for Modulating Protein Function

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