Conditional knockout of the PDK‐1 gene in osteoblasts affects osteoblast differentiation and bone formation

Author:

Bai Yiguang12ORCID,Zhang Qiong3,Chen Qiaoling4,Zhou Quan56,Zhang Yanan5,Shi Zhuohua1,Nong Haibin1,Liu Mingfu1,Zeng Gaofeng3,Zong Shaohui17

Affiliation:

1. Department of Spine Osteopathia The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China

2. Department of Orthopaedics, Nanchong Central Hospital The Second Clinical Institute of North Sichuan Medical College Nanchong Sichuan China

3. Department of Nutrition and Food Hygiene College of Public Hygiene of Guangxi Medical University Nanning Guangxi China

4. Department of Oncology, Nanchong Central Hospital The Second Clinical Institute of North Sichuan Medical College Nanchong Sichuan China

5. Collaborative Innovation Center of Guangxi Biological Medicine Guangxi Medical University Nanning Guangxi China

6. Department of Emergency The Hongqi Hospital Affiliated to Mudanjiang Medical University Mudanjiang Heilongjiang China

7. Research Centre for Regenerative Medicine and Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Nanning Guangxi China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference36 articles.

1. Osteoporosis and osteoblasts cocultured with adipocytes inhibit osteoblast differentiation by downregulating histone acetylation;Abuna R. P. F.;Journal of Cellular Physiology,2020

2. The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype

3. Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

4. Deficiency of Pdk1 contributes to primordial follicle activation via the upregulation of YAP expression and the pro‑inflammatory response;Gao J.;International Journal of Molecular Medicine,2020

5. miR‐483 is downregulated in pre‐eclampsia via targeting insulin‐like growth factor 1 (IGF1) and regulates the PI3K/Akt/mTOR pathway of endothelial progenitor cells;Han L.;The Journal of Obstetrics and Gynaecology Research,2020

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