Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency-Reference-Cited by-同舟云学术

Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency

Published:2016-04-12 Issue:5 Volume:18 Page:482-489
ISSN:1388-9842
Container-title:European Journal of Heart Failure
language:en
Short-container-title:Eur J Heart Fail

Author:

Anker Stefan D.¹,Schroeder Stefan²,Atar Dan³,Bax Jeroen J.⁴,Ceconi Claudio⁵,Cowie Martin R.⁶,Crisp Adam⁷,Dominjon Fabienne⁸,Ford Ian⁹,Ghofrani Hossein-Ardeschir¹⁰¹¹¹²,Gropper Savion¹³,Hindricks Gerhard¹⁴,Hlatky Mark A.¹⁵,Holcomb Richard¹⁶,Honarpour Narimon¹⁷,Jukema J. Wouter⁴,Kim Albert M.¹⁸,Kunz Michael²,Lefkowitz Martin¹⁹,Le Floch Chantal⁸,Landmesser Ulf²⁰,McDonagh Theresa A.²¹,McMurray John J.²²,Merkely Bela²³,Packer Milton²⁴,Prasad Krishna²⁵,Revkin James¹⁸,Rosano Giuseppe M.C.²⁶²⁷,Somaratne Ransi¹⁷,Stough Wendy Gattis²⁸,Voors Adriaan A.²⁹,Ruschitzka Frank³⁰

Affiliation:

1. University Medical Center Gottingen; Gottingen Germany

2. Bayer Healthcare; Berlin Germany

3. Department of Cardiology B; Oslo University Hospital Ulleval and University of Oslo; Norway

4. Department of Cardiology; Leiden University Medical Center; Leiden The Netherlands

5. Unit of Cardiology; Hospital of Desenzano del Garda; Desenzano del Garda Italy

6. National Heart and Lung Institute; Imperial College London; London UK

7. GlaxoSmithKline; Middlesex UK

8. Servier International; Paris France

9. Robertson Centre for Biostatistics; University of Glasgow; Glasgow UK

10. University of Giessen and Marburg Lung Center; UGMLC [member of the German Center for Lung Research (DZL)]; Giessen Germany

11. Kerckhoff-Klinik Bad Nauheim; Germany

12. Imperial College London; UK

13. Boehringer-Ingelheim GmBH & Co. KG; Ingelheim Germany

14. Department of Electrophysiology, Heart Center; University of Leipzig; Leipzig Germany

15. Stanford University School of Medicine; Stanford CA USA

16. Independent Biostatistician; Minneapolis MN USA

17. Amgen, Inc.; Thousand Oaks CA USA

18. Pfizer, Inc.; Cambridge MA USA

19. Novartis Pharmaceuticals; East Hanover NJ USA

20. Department of Cardiology; Charité Universitätsmedizin Berlin; Berlin Germany

21. King's College Hospital; London UK

22. BHF Cardiovascular Research Centre; University of Glasgow; Glasgow UK

23. Semmelweis University Heart and Vascular Center; Budapest Hungary

24. Department of Clinical Sciences; University of Texas Southwestern Medical Center; Dallas TX USA

25. United Kingdom Medicines and Healthcare Products Regulatory Agency; London UK

26. IRCCS San Raffaele Hospital Roma; Rome Italy

27. Cardiovascular and Cell Sciences Institute; St. George's University of London; London UK

28. Campbell University College of Pharmacy and Health Sciences; NC USA

29. University of Groningen; Groningen The Netherlands

30. Department of Cardiology, Heart Failure Clinic and Transplantation; University Heart Center Zurich; Zurich Switzerland

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

Reference62 articles.

1. Clinical outcome endpoints in heart failure trials: a European Society of Cardiology Heart Failure Association consensus document;Zannad;Eur J Heart Fail,2013

2. Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review;Cordoba;BMJ,2010

3. Composite outcomes in randomized trials: greater precision but with greater uncertainty?;Freemantle;JAMA,2003

4. European Network for Health Technology Assessment https://eunethta.fedimbo.belgium.be/sites/5026.fedimbo.belgium.be/files/Clinical%20endpoints.pdf

5. Jackson N Atar D Borentain M Breithardt G van Eickels M Endres M Fraass U Friede T Hannachi H Janmohamed S Kreuzer J Landray M Lautsch D Le Floch C Mol P Naci H Samani N Svensson A Thorstensen C Tijssen J Vandzhura V Zalewski A Kirchhof P Eur Heart J 2016 37 747 754

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