1. Nuffield Department of Clinical Medicine; University of Oxford; Oxford UK
2. Radcliffe Department of Medicine; University of Oxford; Oxford UK
3. Medical Research Council (MRC) Lifecourse Epidemiology Unit; University of Southampton, University Hospital Southampton NHS Foundation Trust; Southampton UK
4. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences; University of Oxford; Oxford UK