Deep gray matter volume loss drives disability worsening in multiple sclerosis

Author:

Eshaghi Arman12ORCID,Prados Ferran1234,Brownlee Wallace J.1,Altmann Daniel R.15,Tur Carmen1,Cardoso M. Jorge23,De Angelis Floriana1,van de Pavert Steven H.1,Cawley Niamh1,De Stefano Nicola6ORCID,Stromillo M. Laura6,Battaglini Marco6ORCID,Ruggieri Serena78,Gasperini Claudio7,Filippi Massimo9,Rocca Maria A.9,Rovira Alex10,Sastre-Garriga Jaume11,Vrenken Hugo12,Leurs Cyra E.13,Killestein Joep13,Pirpamer Lukas14,Enzinger Christian1415,Ourselin Sebastien234,Wheeler-Kingshott Claudia A.M. Gandini11617,Chard Declan14,Thompson Alan J.1,Alexander Daniel C.2ORCID,Barkhof Frederik123412,Ciccarelli Olga14,

Affiliation:

1. Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology; Faculty of Brain Sciences; University College London

2. Centre for Medical Image Computing (CMIC), Department of Computer Science; University College London; London United Kingdom

3. Translational Imaging Group, Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering; University College London; London United Kingdom

4. National Institute for Health Research (NIHR); University College London Hospitals (UCLH) Biomedical Research Centre (BRC); London United Kingdom

5. Medical Statistics Department; London School of Hygiene & Tropical Medicine; London United Kingdom

6. Department of Medicine, Surgery and Neuroscience; University of Siena; Siena Italy

7. Department of Neurosciences; S Camillo Forlanini Hospital; Rome Italy

8. Department of Neurology and Psychiatry; University of Rome Sapienza; Rome Italy

9. Neuroimaging Research Unit, Institute of Experimental Neurology; Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University; Milan Italy

10. MR Unit and Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron; Universitat Autònoma de Barcelona; Barcelona Spain

11. Department of Neurology/Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron; Universitat Autònoma de Barcelona; Barcelona Spain

12. Department of Radiology and Nuclear Medicine; VU University Medical Centre; Amsterdam The Netherlands

13. Department of Neurology, MS Center Amsterdam; VU University Medical Center; Amsterdam The Netherlands

14. Department of Neurology; Medical University of Graz; Graz Austria

15. Division of Neuroradiology, Vascular & Interventional Radiology, Department of Radiology; Medical University of Graz; Graz Austria

16. Department of Brain and Behavioral Sciences; University of Pavia; Pavia Italy

17. Brain MRI 3T Mondino Research Center; C. Mondino National Neurological Institute; Pavia Italy

Funder

ECTRIMS-MAGNIMS Fellowship

MSIF

National Institute for Health Research

ECTRIMS

EPSRC

European Union's Horizon 2020 research and innovation programme

UK MS Society

Michael J. Fox Foundation for Parkinson's Research

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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