The rapid enrollment design for Phase I clinical trials

Author:

Ivanova Anastasia1,Wang Yunfei2,Foster Matthew C.3

Affiliation:

1. Department of Biostatistics; University of North Carolina at Chapel Hill; Chapel Hill NC 27599-7420 U.S.A.

2. Departments of Pediatrics and Biostatistics; George Washington University and Children's National Medical Center; Washington DC 20010 U.S.A.

3. University of North Carolina; Lineberger Comprehensive Cancer Center, Chapel Hill; NC 27599 U.S.A.

Funder

National Institutes of Health

Publisher

Wiley

Subject

Statistics and Probability,Epidemiology

Reference18 articles.

1. Sequential estimation of quantal response curves;Wetherill;Journal of the Royal Statistical Society B,1963

2. Continual reassessment method: a practical design for phase 1 clinical trials in cancer;O'Quigley;Biometrics,1990

3. Cancer phase I clinical trials: efficient dose escalation with overdose control;Babb;Statistics in Medicine,1998

4. Escalation with overdose control using time to toxicity for cancer phase I clinical trials;Tighiouart;PloS One,2014 Mar 24

5. Adaptive clinical trial designs for phase I cancer studies;Sverdlov;Statistics Surveys,2014

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