The cancer‐related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis

Author:

Villanueva Francisco12,Araya Hector12,Briceño Pedro12,Varela Nelson13,Stevenson Andres12,Jerez Sofia12,Tempio Fabian14,Chnaiderman Jonas5,Perez Carola6,Villarroel Milena78,Concha Emma7,Khani Farzaneh910,Thaler Roman910,Salazar‐Onfray Flavio14,Stein Gary S11,van Wijnen Andre J.910ORCID,Galindo Mario12ORCID

Affiliation:

1. Millennium Institute on Immunology and Immunotherapy, University of Chile Santiago Chile

2. Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile Santiago Chile

3. Department of Medical Technology Faculty of Medicine, University of Chile Santiago Chile

4. Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile Santiago Chile

5. Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile Santiago Chile

6. Laboratory Animal Facility, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile Santiago Chile

7. Department of Oncology Hospital Dr. Luis Calvo Mackenna Santiago Chile

8. National Child Programme of Antineoplastic Drugs (PINDA) Santiago Chile

9. Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota

10. Department of Biochemistry and Molecular Biology Mayo Clinic Rochester Minnesota

11. Department of Biochemistry University of Vermont Cancer Center, The Robert Larner College of Medicine, University of Vermont Burlington Vermont

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

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