N,N‐Dimethyl Formamide European Restriction Demands Solvent Substitution in Research and Development

Author:

Sherwood James1ORCID,Albericio Fernando2,de la Torre Beatriz G.3

Affiliation:

1. Green Chemistry Centre of Excellence Department of Chemistry University of York Heslington North Yorkshire UK. YO10 5DD

2. School of Chemistry and Physics University of KwaZulu-Natal Durban 4000 South Africa

3. School of Laboratory Medicine and Medical Sciences University of KwaZulu-Natal Durban 4001 South Africa

Abstract

AbstractAs of December 2023, the use of common solvent N,N‐dimethyl formamide (DMF) will be restricted in the European Union because of its reproductive health hazard. Industrial facilities must comply with stricter exposure limits, and researchers are recommended to find alternative solvents. Here we explain the restrictions on DMF, which disciplines are affected, and how to substitute DMF to keep research and development commercially relevant.

Publisher

Wiley

Reference85 articles.

1. European Chemicals Agency (ECHA) “Committee for risk assessment (RAC) committee for socio-economic analysis (SEAC) opinion on an annex XV dossier proposing restrictions on N N-dimethylformamide – adopted” can be found underhttps://echa.europa.eu/documents/10162/44ad5cd9-1143-0072-0550-5860846ffbb4 2019(accessed: 26th August 2023).

2. International Union of Pure and Applied Chemistry (IUPAC) “Compendium of chemical terminology 2nd ed. (the ‘gold book’): dipolar aprotic solvent” can be found underhttps://goldbook.iupac.org/terms/view/D01751 1994(accessed: 26th August 2023).

3. Studies on the prenatal toxicity of N,N-dimethylformamide in mice, rats and rabbits

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