Scalability of Pharmaceutical Co‐Crystal Formation by Mechanochemistry in Batch

Author:

Bodach Alexander1,Portet Anaïs2,Winkelmann Frederik1,Herrmann Bastian1,Gallou Fabrice3,Ponnusamy Ettigounger4,Virieux David2,Colacino Evelina2ORCID,Felderhoff Michael1ORCID

Affiliation:

1. Department of Heterogeneous Catalysis Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 1 D-45470 Mülheim an der Ruhr Germany

2. ICGM Univ Montpellier CNRS ENSCM Montpellier France

3. Novartis Pharma AG CH-4057 Basel Switzerland

4. Merck SIGMA-ALDRICH Production GmbH Industriestrasse 25 CH-9471 Buchs Switzerland

Abstract

AbstractThe development of mechanochemistry is considerably growing. Benign by design, this technology complies with several principles of green chemistry, contributing to the achievement of the United Nations Sustainable Development Goals (UN SDGs) and the European Green Deal objectives. Herein, we report the use of mechanochemical processes in batch to prepare kilogram‐scale of the Active Pharmaceutical Ingredient (API): Ibuprofen‐Nicotinamide (rac‐IBP:NCT) co‐crystal in an industrial eccentric vibration mill. This scenario shows a sustainable approach to the industrial up‐scaling of pharmaceutical co‐crystals by a solvent‐free mechanochemical process in batch. The quantitative assessment of the greenness of the mechanochemical process against the Twelve Principles of Green Chemistry was performed using the DOZN 2.0 Green Chemistry Evaluator.

Publisher

Wiley

Subject

General Energy,General Materials Science,General Chemical Engineering,Environmental Chemistry

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