Neuronal current imaging of epileptic activity: An MRI study in patients with a first unprovoked epileptic seizure

Abstract

AbstractObjectiveThis study evaluates the performance of the novel MRI sequence stimulus‐induced rotary saturation (SIRS) to map responses to interictal epileptic activity in the human cortex. Spin‐lock pulses have been applied to indirectly detect neuronal activity through magnetic field perturbations. Following initial reports about the feasibility of the method in humans and animals with epilepsy, we aimed to investigate the diagnostic yield of spin‐lock MR pulses in comparison with scalp‐EEG in first seizure patients.MethodsWe employed a novel method for measurements of neuronal activity through the detection of a resonant oscillating field, stimulus‐induced rotary saturation contrast (SIRS) at spin‐lock frequencies of 120 and 240 Hz acquired at a single 3T MRI system. Within a prospective observational study, we conducted SIRS experiments in 55 patients within 7 days after a suspected first unprovoked epileptic seizure and 61 healthy control subjects. In this study, we report on the analysis of data from a single 3T MRI system, encompassing 35 first seizure patients and 31 controls.ResultsThe SIRS method was applicable in all patients and healthy controls at frequencies of 120 and 240 Hz. We did not observe any significant age‐ or sex‐related differences. Specificity of SIRS at 120 Hz was 90.3% and 93.5% at 240 Hz. Sensitivity was 17.1% at 120 Hz and 40.0% at 240 Hz.SignificanceSIRS targets neuronal oscillating magnetic fields in patients with epilepsy. The coupling of presaturated spins to epilepsy‐related magnetic field perturbations may serve as a—at this stage experimental—diagnostic test in first seizure patients to complement EEG findings as a standard screening test.Plain Language SummaryRoutine diagnostic tests carry several limitations when applied after a suspected first seizure. SIRS is a noninvasive MRI method to enable time‐sensitive diagnosis of image correlates of epileptic activity with increased sensitivity compared to routine EEG.