Revisiting the putative role of heme as a trigger of inflammation
Author:
Affiliation:
1. Division of Internal Medicine; University of Zurich; Zurich Switzerland
2. Center of Biologics Evaluation and Research (CBER); FDA; Silver Spring MD USA
Funder
Kommission für Technologie und Innovation
Swiss Federal Commission for Technology and Innovation
Promedica Foundation
Novartis Foundation
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,Neurology
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3. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase;Wagener;Blood,2001
4. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy;Baek;J Clin Invest,2012
5. Points of control in inflammation;Nathan;Nature,2002
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