Randomized, placebo-controlled single-ascending-dose study to evaluate the safety, tolerability and pharmacokinetics of the HIV nucleoside reverse transcriptase inhibitor, BMS-986001, in healthy subjects

Author:

Urata Y.1,Paintsil E.2,Cheng Y.-C.3,Matsuda T.1,Sevinsky H.4,Hawthorne D.4,Bertz R.4,Hanna G.J.4,Grasela D.4,Hwang C.4

Affiliation:

1. Oncolys BioPharma; Tokyo Japan

2. Department of Pediatrics and Department of Pharmacology; Yale University School of Medicine; New Haven CT USA

3. Department of Pharmacology; Yale University School of Medicine; New Haven CT USA

4. Bristol-Myers Squibb; Research and Development; Princeton NJ USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference30 articles.

1. European AIDS Clinical Society http://www.europeanaidsclinicalsociety.org/images/stories/EACS-Pdf/EACSGuidelines-v6.1-English.pdf

2. Panel on Antiretroviral Guidelines for Adults and Adolescents http://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf

3. World Health Organization http://whqlibdoc.who.int/publications/2010/9789241599764_eng.pdf

4. Antiretroviral use and other risks for HIV-associated neuropathies in an international cohort;Cherry;Neurology.,2006

5. Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine and hydroxyurea;Moore;AIDS.,2000

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