Mechanistic modeling of a human IgG <sub>4</sub> monoclonal antibody (tralokinumab) Fab‐arm exchange with endogenous IgG <sub>4</sub> in healthy volunteers-Reference-Cited by-同舟云学术

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Mechanistic modeling of a human IgG ₄ monoclonal antibody (tralokinumab) Fab‐arm exchange with endogenous IgG ₄ in healthy volunteers

Published:2022-01-12 Issue:4 Volume:11 Page:438-446
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacom & Syst Pharma

Author:

Wang Bing¹,Goodman Jo²,Roskos Lorin K.³

Affiliation:

1. Amador Bioscience Pleasanton California USA

2. Clinical Pharmacology and Safety Sciences AstraZeneca BioPharmaceuticals, R&D Cambridge UK

3. Clinical Pharmacology and Safety Sciences AstraZeneca BioPharmaceuticals, R&D Gaithersburg Maryland USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12738

Reference23 articles.

1. Treatment of atopic dermatitis with tralokinumab, an anti–IL-13 mAb

2. Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma

3. An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease

4. Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology

5. Isotype selection in antibody engineering

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