Use of
physiologically‐based
pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity
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Published:2022-05-02
Issue:6
Volume:11
Page:778-791
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ISSN:2163-8306
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Container-title:CPT: Pharmacometrics & Systems Pharmacology
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language:en
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Short-container-title:CPT Pharmacom & Syst Pharma
Author:
Gerhart Jacqueline G.1ORCID, Carreño Fernando O.1ORCID, Ford Jennifer L.1ORCID, Edginton Andrea N.2ORCID, Perrin Eliana M.3ORCID, Watt Kevin M.4ORCID, Muller William J.5, Atz Andrew M.6ORCID, Al‐Uzri Amira7, Delmore Paula8, Gonzalez Daniel1ORCID, Benjamin Daniel K., Hornik Christoph, Zimmerman Kanecia, Kennel Phyllis, Beci Rose, Dang Hornik Chi, Kearns Gregory L., Laughon Matthew, Paul Ian M., Sullivan Janice, Wade Kelly, Delmore Paula, Taylor‐Zapata Perdita, Lee June, Anand Ravinder, Sharma Gaurav, Simone Gina, Kaneshige Kim, Taylor Lawrence, Al‐Uzri Amira, Hornik Chi, Sokol Gregory, Speicher David, Sullivan Janice, Mourani Peter, Mendley Susan, Meyer Marisa, Atkins Robert, Flynn Joseph, Vaughns Janelle, Sherwin Catherine, Delmore Paula, Goldstein Stuart, Rathore Mobeen, Melloni Chiara, Muller William, Delmore Paula, Tremoulet Adriana, James Laura, Mendley Susan, Blackford Martha, Atz Andrew, Adu‐Darko Michelle, Mourani Peter, Watt Kevin, Hornik Chi, Al‐Uzri Amira, Sullivan Janice, Laughon Matthew, Brian Smith P., Watt Kevin, Cheifetz Ira, Atz Andrew, Bhatt‐Mehta Varsha, Fernandez Allison, Lowry Jennifer,
Affiliation:
1. Division of Pharmacotherapy and Experimental Therapeutics, The University of North Carolina Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA 2. School of Pharmacy University of Waterloo Waterloo Ontario Canada 3. Department of Pediatrics, School of Medicine and School of Nursing Johns Hopkins University Baltimore Maryland USA 4. Division of Pediatric Clinical Pharmacology, School of Medicine University of Utah Salt Lake City Utah USA 5. Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA 6. Medical University of South Carolina Children's Hospital Charleston South Carolina USA 7. Oregon Health and Science University Portland Oregon USA 8. Wesley Medical Center Wichita Kansas USA
Funder
National Institutes of Health American Foundation for Pharmaceutical Education National Institute of General Medical Sciences Eunice Kennedy Shriver National Institute of Child Health and Human Development
Subject
Pharmacology (medical),Modeling and Simulation
Reference48 articles.
1. Prevalence of Obesity and Severe Obesity in US Children, 1999–2016 2. World Health Organization.Report of the commision on ending childhood obesity. WHO Doc Prod Serv;2016. Accessed November 14 2020.https://apps.who.int/iris/bitstream/handle/10665/204176/9789241510066_eng.pdf;sequence=1 3. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults 4. Association between childhood obesity and use of regular medications in the UK: longitudinal cohort study of children aged 5–11 years;Solmi F;Br Med J Open,2015 5. Medication Use Among Children <12 Years of Age in the United States: Results From the Slone Survey
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