A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP‐1 dual agonist-Reference-Cited by-同舟云学术

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A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP‐1 dual agonist

Published:2021-12-24 Issue: Volume: Page:
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacom & Syst Pharma

Author:

Bosch Rolien¹,Petrone Marcella²,Arends Rosalin³,Vicini Paolo²,Sijbrands Eric J. G.⁴,Hoefman Sven¹,Snelder Nelleke¹

Affiliation:

1. LAP&P Consultants Leiden The Netherlands

2. Clinical Pharmacology and Safety Sciences AstraZeneca Cambridge UK

3. AstraZeneca Gaithersburg Maryland USA

4. Department of Internal Medicine Erasmus MC University Medical Center Rotterdam The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12752

Reference48 articles.

1. No Guts, No Loss: Toward the Ideal Treatment for Obesity in the Twenty-First Century

2. Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus

3. What is Diabetes Remission?

4. Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

5. MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quantification of the effect of GLP‐1R agonists on body weight using in vitro efficacy information: An extension of the Hall body composition model;CPT: Pharmacometrics & Systems Pharmacology;2024-06-12

2. Characterisation of cotadutide's dual GLP‐1/glucagon receptor agonistic effects on glycaemic control using an in vivo human glucose regulation quantitative systems pharmacology model;British Journal of Pharmacology;2024-02-25

3. Mathematical modeling clarifies the paracrine roles of insulin and glucagon on the glucose-stimulated hormonal secretion of pancreatic alpha- and beta-cells;Frontiers in Endocrinology;2023-08-14

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