Physiologically‐based pharmacokinetic modeling to predict CYP3A4‐mediated drug‐drug interactions of finerenone
Author:
Affiliation:
1. Pharmaceuticals R&D, Pharmacometrics Bayer AG Leverkusen Germany
2. Pharmaceuticals R&D, Drug Metabolism and Pharmacokinetics Bayer AG Wuppertal Germany
3. Pharmaceuticals R&D, Clinical Pharmacology Bayer AG Wuppertal Germany
Publisher
Wiley
Subject
Pharmacology (medical),Modeling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12746
Reference49 articles.
1. Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes;Bakris GL;N Engl J Med,2020
2. Biotransformation of finerenone, a novel nonsteroidal mineralocorticoid receptor antagonist, in dogs, rats, and humans, in vivo and in vitro;Gerisch M;Drug Metab Dispos,2018
3. Pharmacokinetics of the novel, selective, non‐steroidal mineralocorticoid receptor antagonist finerenone in healthy volunteers: results from an absolute bioavailability study and drug‐drug interaction studies in vitro and in vivo;Heinig R;Eur J Drug Metab Pharmacokinet,2018
4. Pharmacokinetics of the novel nonsteroidal mineralocorticoid receptor antagonist finerenone (BAY 94–8862) in individuals with mild or moderate hepatic impairment;Heinig R;Eur J Drug Metab Pharmacokinet,2019
5. Results from drug‐drug interaction studies in vitro and in vivo investigating the effect of finerenone on the pharmacokinetics of comedications;Heinig R;Eur J Drug Metab Pharmacokinet,2020
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