Assessing survival outcomes of patients with oral tongue squamous cell carcinoma: Focus on age, sex, and stage-Reference-Cited by-同舟云学术

Assessing survival outcomes of patients with oral tongue squamous cell carcinoma: Focus on age, sex, and stage

Published:2024-05-02 Issue:9 Volume:46 Page:2167-2177
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Pamulapati Saagar¹^ORCID,Abousaud Marin²,Li Yixuan³,Ekpenyong Asari⁴,Rudra Soumon⁵,Remick Jill S.⁵,Bates James E.⁵^ORCID,Stokes William A.⁵^ORCID,McDonald Mark W.⁵^ORCID,Schmitt Nicole C.⁶^ORCID,El‐Deiry Mark W.⁶,Patel Mihir R.⁶^ORCID,Steuer Conor E.⁴,Switchenko Jeffrey M.³,Shin Dong M.⁴^ORCID,Teng Yong⁴^ORCID,Hammond Anthea⁴,Saba Nabil F.⁴^ORCID

Affiliation:

1. Internal Medicine Program Mercyhealth Graduate Medical Education Consortium Rockford Illinois USA

2. Astellas Pharma Global Development Inc., Astellas Pharma Northbrook Illinois USA

3. Department of Biostatistics and Bioinformatics Rollins School of Public Health, Emory University Atlanta Georgia USA

4. Department of Hematology and Medical Oncology Emory University Atlanta Georgia USA

5. Department of Radiation Oncology Emory University Atlanta Georgia USA

6. Department of Otolaryngology Emory University Atlanta Georgia USA

Abstract

AbstractBackgroundThe purpose of this study was to provide further insights into whether age and/or sex are associated with prognosis in oral tongue squamous cell carcinoma.MethodsThis was a retrospective cohort study utilizing hospital registry data from 2006 to 2016 obtained from the National Cancer Database. Identified patients were divided into various cohorts based on age, sex, and staging. A descriptive analysis was performed using chi‐square tests and overall survival rates were estimated using Kaplan–Meier method.ResultsA total of 17 642 patients were included in the study. The 5‐year overall survival rates were 82.0% (95% CI: 79.8%–84.0%) in younger patients versus 67.5% (95% CI: 66.7%–68.3%, p‐value <0.0001) older patients. The median overall survival for females was 143.4 months (95% CI: 133.2–NA) versus 129.8 (95% CI: 125.4–138.7, p‐value <0.0001) in males.ConclusionsOur analysis suggests that younger age and female sex are both predictors of improved survival in oral tongue squamous cell carcinoma.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27786

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