Alternating flow filtration as an alternative to internal spin filter based perfusion process: Impact on productivity and product quality

Author:

Bosco Belén1,Paillet Cristian1,Amadeo Ignacio12,Mauro Laura1,Orti Eduardo1,Forno Guillermina12

Affiliation:

1. Zelltek S.A. RN 168, Parque Tecnológico Litoral Centro; (3000) Santa Fe Argentina

2. Laboratorio de Cultivos Celulares, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral; (3000) Santa Fe Argentina

Publisher

Wiley

Subject

Biotechnology

Reference16 articles.

1. Very high density of chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE BioreactorTM. II. Applications for antibody production and cryopreservation;Clincke;Biotechnol Prog.,2013

2. The use of the ATF system to culture Chinese Hamster ovary cells in a concentrated fed-batch system;Nieminen;BioPharm Int.,2011

3. Industrial choices for protein production by large-scale cell culture;Chu;Curr Opin Biotechnol.,2001

4. Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production;Tapia;Appl Microbiol Biotechnol.,2016

5. Chotteau V Tördahl K Perroud P. 21st ESACT Meeting 2009

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